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#cancer

5 posts5 participants0 posts today
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JL Lycette MD, author🩺📚

I can’t get over the cognitive dissonance of spending 12 hours of intense work in clinic, using every minute of my 25 years of training and experience to formulate treatment plans for my patients with #cancer, and then to come home and check the news and to read about every part of the infrastructure needed to attain the knowledge for these treatment plans bring intentionally dismantled

#MedMastodon#healthcare#science
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Ned Yeung

The mRNA technology behind coronavirus vaccines is now being used to create bespoke vaccines for cancer patients.

"Cancer vaccines weren’t a proper field of research before the pandemic. There was nothing. Apart from one exception, pretty much every clinical trial had failed. With the pandemic, however, we proved that mRNA vaccines were possible.

mRNA cancer vaccines work by giving the body instructions to make a harmless piece of a cancer-related protein. This trains the immune system to recognize and attack cancer cells carrying that protein. Think of it like a training manual for security guards. The vaccine gives the immune system a guide on what cancer looks like, so it knows exactly who to watch for and remove.

Going from mRNA Covid vaccines to mRNA cancer vaccines is straightforward: same fridges, same protocol, same drug, just a different patient.

In the current trials, we do a biopsy of the patient, sequence the tissue, send it to the pharmaceutical company, and they design a personalized vaccine that’s bespoke to that patient’s cancer. That vaccine is not suitable for anyone else. It’s like science fiction.

The UK was ready. We had fridges and we had world-class manufacturing and research facilities. During the pandemic, we had proven we could open and deliver clinical trials fast. Also, the UK had established a genomic global lead with Genomics England and the 100,000 Genome Project. All doctors and nurses in this country are trained in genomics.

So the UK government signed two partnerships: one with BioNTech to provide 10,000 patients with access to personalized cancer treatments by 2030, and a 10-year investment with Moderna in an innovation and technology center with capacity to produce up to 250 million vaccines. The stars were aligned.

For many years, we believed that research is inherently slow. It used to take 20 years to get a drug to market. Most cancer patients, unfortunately, will succumb by the time a drug gets to market. We showed the world that it could be done in a year if you modernize your process, run parts of the process in parallel, and use digital tools.

We have a trial to stop skin cancer coming back after you cut it out. It’s now completed. We over-recruited again, just like every single one of the trials that we ran, and the trial finished one year ahead of schedule. That’s completely unheard of in cancer trials because they normally run over-long.

What will happen now is that, over the next six to 12 months, we will monitor the people in the trial and work out if there’s a difference between the people who took the cancer vaccine and the ones who didn’t. We’re hoping to have results by the end of the year or beginning of 2026. If it’s successful, we will have invented the first approved personalized mRNA vaccine, within only five years of the first licensed mRNA vaccine for Covid. That’s pretty impressive."

- Dr. Lennard Lee, UK National Health Service oncologist and medical director at the Ellison Institute of Technology in Oxford

wired.com/story/wired-health-l

WIRED · Covid Vaccines Have Paved the Way for Cancer VaccinesBy João Medeiros
#cancer#vaccination#Science
Public
Marie 🇸🇪

Scientists at KAIST have made a groundbreaking discovery in cancer treatment by reversing colon cancer cells back into normal ones instead of destroying them. This approach focuses on using digital twin technology to simulate & analyze gene interactions, identifying key molecular switches that trigger this transformation.

If further research supports these findings, it could revolutionize cancer therapy, providing new hope for patients worldwide.

Bye cancer! South Korean scientists unveil technology that turns cancer cells back into normal cells. Credits): KAIST/Keck School of Medicine.
#cancer#southkorea#Science
Replied in thread
Public
Zhi Zhu 🕸️

Act Now
talkingpointsmemo.com/edblog/a

" #DOGE and #DonaldTrump are trying to shut down advanced medical #research, especially #cancer research, in the #UnitedStates...

Reporting is inevitably focused on canceled grants, dismissed researchers, bans on certain forms of #communication...

What’s important is this bigger picture...

They’re shutting down medicine/disease research... throughout the United States."

Text from article(edited for length): ...I think it’s important to state categorically and clearly: DOGE and Donald Trump are trying to shut down advanced medical research, especially cancer research, in the United States... Reporting is inevitably focused on canceled grants, dismissed researchers, bans on certain forms of communication, on and off-again bans on travel, grant review processes halted. ...Reporting has a hard time stepping back and evaluating the systemic picture, goals and inevitable outcomes. If you shut down cell respiration in an organism, the organism will die. And that’s a decent model for what’s happening in these organizations. Only it’s not just cell respiration – it’s every other foundational life process, along with whole digits and limbs simply being removed all at once and carted off for disposal. My point is simple. We – and I’ve been guilty of this myself – get pulled into each strand of the story: travel, comms, paused grants. What’s important is this bigger picture. It has to be seen as such. They’re shutting down medicine/disease research in the federal government and the government-run and funded ecosystem of funding for most research throughout the United States. It’s not hyperbole. That’s happening. You can’t try to stop something unless you understand it. There’s that final point at which the body dies. It becomes a corpse. It can’t be revived.
#ElonMusk#Musk#Coup
Continued thread
Public
Nonilex

The #EPA considers #chloroprene —which is used to make synthetic rubber—a likely #carcinogen, & the suit sought to compel the plant to curb these #emissions.

#Trump ofcls’ decision to abandon the case…has prompted alarm from #environmental & #PublicHealth advocates. They warn that the plant’s continued operations could harm the #health of thousands of residents, including hundreds of young #children who are especially vulnerable to carcinogens.

#law#DOJ#justice
Public
Nonilex

#Trump’s #DOJ is to drop suit over alleged #cancer-causing #pollution

#Justice is poised to drop a landmark lawsuit alleging that cancer-causing pollution from a #Louisiana #petrochemical plant poses an imminent danger to nearby communities….

The lawsuit alleges that the Denka Performance Elastomer plant in #LaPlace, LA, threatens local residents by releasing unsafe levels of the #toxic #chemical #chloroprene.

#law #PublicHealth #health #environment #USpol
washingtonpost.com/climate-env

The Washington Post · Biden said this plant was a health threat. Trump’s ready to drop a lawsuit against itBy Maxine Joselow
Public
earthling

The End of Your Life Book Club by Will Schwalbe, 2012

"What are you reading?"

That's the question Will Schwalbe asks his mother, Mary Anne, as they sit in the waiting room of the Memorial Sloan-Kettering Cancer Center. In 2007, Mary Anne returned from a humanitarian trip to Pakistan and Afghanistan suffering from what her doctors believed was a rare type of hepatitis.

@bookstodon
#books
#reading
#BookClubs
#cancer

Months later she was diagnosed with a form of advanced pancreatic cancer, which is almost always fatal, often in six months or less. This is the inspiring true story of a son and his mother, who start a "book club" that brings them together as her life comes to a close. Over the next two years, Will and Mary Anne carry on conversations that are both wide-ranging and deeply personal, prompted by an eclectic array of books and a shared passion for reading. Their list jumps from classic to popular, from poetry to mysteries, from fantastic to spiritual. The issues they discuss include questions of faith and courage as well as everyday topics...
Continued thread
Public
earthling

@bookstodon

It allows a person with cancer to concentrate on living the best life possible, despite an uncertain future. Patients at every stage will find Living with Cancer a comprehensive, thoughtful, and accessible guide for navigating the illness and its treatment.

#cancer
Public
Megaphone :verified:
#ScienceUnderSiege: The Orlando Research Conference Fallout

Something alarming is happening in the #ScientificCommunity, and it’s not getting the attention it deserves. A recent #NIH-backed #neuroscience conference in #Orlando turned into a disaster. Research sessions were canceled after being mistaken for “#DEI” initiatives, and funding was pulled.

One session on the diversity of afferent firing in the cochlea (how nerve cells transmit sound) was targeted because people saw the word “#diversity” and assumed it was political. #MAGA hat-wearing attendees reportedly vandalized posters.

The nescient reaction of the MAGA hat-wearing attendees to the word “diversity”—mistaking a scientific discussion on neural firing patterns in the cochlea for a political agenda—exemplifies a dangerous blend of #ignorance and ideological rigidity. Their inability to differentiate between linguistic context and #partisan buzzwords not only disrupted legitimate research but also underscored the broader issue of anti-intellectualism undermining scientific progress.

Worse, researchers discovered their already earned funding was revoked, postdoc opportunities disappeared, and the conference felt like a #funeral for the field as careers crumbled in real time.

Meanwhile, the NIH was banned from attending due to a new administration-imposed blackout on communications and travel, delaying critical #research on #Cancer, #HeartDisease, and #Diabetes.

#Science depends on open inquiry—but now, #political interference is gutting #research. This isn’t just about one conference. It’s a direct attack on scientific progress. If we don’t stand up now, what’s next?

🔬 Science must remain free from political control.

#ScienceUnderAttack #ResearchMatters #SaveScience #FreedomOfInquiry #ScienceNotPolitics #AcademicFreedom
#academicfreedom
Public
Duck Marshall 🚲

I've finished #quilting this lap quilt! It's not particularly large but it's taken me a year to complete and it's absolutely been a labour of love. I have a deeper appreciation for hand stitching!

I'm sending it to my sister who's still undergoing chemo, with a note that says "each stitch is a prayer for your good health and happiness" and some photos of it in progress so she can see how many stitches actually went into it.

A transparent A4 weston box with a quilt inside, the lid open and resting on the side of it. The quilt is folded so that the central yellow and red starburst is in the centre of the box. At the centre of the starburst is a hand-drawn panel of The Little Prince standing with a rose and a fox. Also resting on the corner of the box is a photo of the quilter sewing the quilt.
A full view of the front of the quilt. The quilt is in three main sections, the centre is a round starburst in yellow, red, and lavender, squared out by white fabric with small green, red, and blue stars. At the centre of the starburst is a hand-drawn image from The Little Prince including the prince on his planet, a rose, and a fox. The hair of the little prince has been satin stitched in yellow, the rose is 3D embroidered, and the fox's tail has also been satin stitched to give it the illusion of fluffiness. To either side of the starburst square are two squares: One of the squares is a Bright Hopes Star with the centre square matching the white star field, framed by red to match the starburst, with yellow rays to match the starburst. The field is lavender as in the starburst. The other square is navy blue with appliqued planets in yellow and red with yellow and red embroidered stars. A light green is used around the two squares to make them the same height as the starburst, and another strip of the same light green is on the outside to make the quilt a little wider. Each block of light green has a different style of top stitching, including straight lines, zigzags, and some hexagonal sashiko. The whole quilt is bordered with a dark green.
#sewing#quilt#cancer
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